Title | MR Characterization of Hepatic Storage Iron in Transfusional Iron Overload |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Tang H, Jensen JH, Sammet CL, Sheth S, Swaminathan SV, Hultman K, Kim D, Wu EX, Brown TR, Brittenham GM |
Journal | J Magn Reson Imaging |
Volume | 39 |
Issue | 2 |
Pagination | 307-16 |
Date Published | 2014 Feb |
ISSN | 1522-2586 |
Keywords | Adult, Blood Transfusion, Female, Humans, Image Interpretation, Computer-Assisted, Iron, Iron Overload, Liver, Liver Diseases, Magnetic Resonance Imaging, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Thalassemia, Tissue Distribution |
Abstract | PURPOSE: To quantify the two principal forms of hepatic storage iron, diffuse, soluble iron (primarily ferritin), and aggregated, insoluble iron (primarily hemosiderin) using a new MRI method in patients with transfusional iron overload. MATERIALS AND METHODS: Six healthy volunteers and 20 patients with transfusion-dependent thalassemia syndromes and iron overload were examined. Ferritin- and hemosiderin-like iron were determined based on the measurement of two distinct relaxation parameters: the "reduced" transverse relaxation rate, RR2 , and the "aggregation index," A, using three sets of Carr-Purcell-Meiboom-Gill (CPMG) datasets with different interecho spacings. Agarose phantoms, simulating the relaxation and susceptibility properties of tissue with different concentrations of dispersed (ferritin-like) and aggregated (hemosiderin-like) iron, were used for validation. RESULTS: Both phantom and in vivo human data confirmed that transverse relaxation components associated with the dispersed and aggregated iron could be separated using the two-parameter (RR2 , A) method. The MRI-determined total hepatic storage iron was highly correlated (r = 0.95) with measurements derived from biopsy or biosusceptometry. As total hepatic storage iron increased, the proportion stored as aggregated iron became greater. CONCLUSION: This method provides a new means for noninvasive MRI determination of the partition of hepatic storage iron between ferritin and hemosiderin in iron overload disorders. |
DOI | 10.1002/jmri.24171 |
Alternate Journal | J Magn Reson Imaging |
PubMed ID | 23720394 |
PubMed Central ID | PMC3761000 |
Grant List | R01-DK066251 / DK / NIDDK NIH HHS / United States R01-DK069373 / DK / NIDDK NIH HHS / United States R01-DK049108 / DK / NIDDK NIH HHS / United States R01 DK049108 / DK / NIDDK NIH HHS / United States R01 DK069373 / DK / NIDDK NIH HHS / United States R01 DK066251 / DK / NIDDK NIH HHS / United States |